Management considerations following overdoses of modified-release morphine preparations
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Massive overdoses with sustained-release lithium carbonate preparations: pharmacokinetic model based on two case studies.
Clinically significant delayed absorption after lithium overdose has been reported previously without adequate explanation. We have studied two patients after they took massive intentional lithium overdoses. The first patient presented shortly after ingesting 74 g of lithium carbonate. Pharmacokinetic analysis with a multicompartmental model of 29 serum lithium concentrations during 300 h (incl...
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The first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using PEG 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. The second objective was to apply the modified solvent method for preparation of sustained re...
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cancer pain. The oral route is the first choice in administering medication to relieve it, but clinical experience has shown that alternative routes of administration should be employed for patients suffering from nausea and vomiting. Furthermore, as morphine is subjected to the extensive first-pass metabolism after oral administration, the rectal administration of morphine, which can partially...
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OBJECTIVE To evaluate pharmaceutical and pharmacotherapeutic differences in oral opioid modified-release products used in the management of chronic pain. DATA SOURCES Searches of MEDLINE (1966-May 2006) and an extensive review of peer reviewed journals were conducted using the key search terms opioid, morphine, hydromorphone, and oxycodone. Supplemental information was gathered through the Am...
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Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioural disorder in childhood, affecting over 5% of children worldwide. As well as the core symptoms of inattention, hyperactivity and impulsivity, patients often exhibit learning difficulties and impairment in social functioning. The frequency of referral is higher for boys than for girls (about 2:1), and g...
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